Molecular Genetics
Students must know...
- The structure of DNA
- The conclusions that resulted from the work of
- Griffith
- Avery-MacLeod-McCarty
- Hershey & Chase
- Wilkins & Franklin
- Watson & Crick
- Replication is semiconservative and occurs 5' to 3'
- The roles of DNA polymerase, ligase, helicase, and topoisomerase in replication
- The general differences between bacterial and eukaryotic chromosomes
- How DNA packaging can effect gene expression
- How DNA & RNA are similar and different, and how this defines their roles
- The differences between replication, transcription, and translation and the role of DNA and RNA in each process
- How eukaryotic cells modify their RNA after transcription
- How genetic information is translated into polypeptides
- How mutations can change the amino acid sequence of a protein and be able to predict how a mutation can result in changes in gene expression
- The components of a virus
- The differences between the lytic and lysogenic cycles
- How viruses can introduce genetic variation into host organisms
- Mechanisms that introduce genetic variation into viral populations.
- Genes can be activated (inducers) or inhibited (repressors) as they interact with regulatory proteins
- A regulatory gene is a sequence of DNA that codes for regulatory proteins
- How the components of an operon function to regulate gene expression
- How positive and negative control function in gene expression
- The impact of DNA methylation & acetylation on gene expression
- How timing and coordination of specific events are regulated in normal development, including pattern formation and induction
- The role of microRNAs in control of cellular functions
- The role of gene regulation in embryonic development and cancer
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Lectures
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Video Assignment
Activity Handouts & Models